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Information Library - Research - Anti-Bacterial

Layman's Introduction

Bacteria are single cell microscopic organisms that inhabit all parts of the Earth and all life on earth. Bacteria have many positive effects for life and human and animal life would not be possible without bacteria. Positive effects include the recycling of nutrients and the fixing of nitrogen from the air making nitrogen available for plants to use. There are approximately 10 times more bacterial cells on and in a human body than there are human cells. Most bacteria on and in the human body have no effect because of the immune system and some are even beneficial for human processes such as digestion. However, there are also a wide range of bacteria that are the causes of human diseases. These diseases include respiratory diseases, syphilis, tetanus, typhoid fever and many more. Some of the diseases are merely irritants and some are life threatening such as bubonic plague.

For the last generation or so anti-biotics have provided an effective treatment for many bacterial infections. More recently, however, largely as a result of overuse of anti-biotics, many bacteria have mutated to be resistant to the anti-biotics that were commonly available and even to the most expensive and seldom used anti-biotics. Some mutations appear to have provided resistance to all known anti-biotics such as the NDM-1 mutation that provides resistance against a wide range of anti-biotics known as beta-lactam anti-bacterials.

In situations where resistance has developed CHD-FA was used together with the now ineffective drugs. The combinations of CHD-FA and the ineffective drugs were shown to be effective. This means that many well known brand names may have a new lease of life if combined with CHD-FA. Because of the synergies demonstrated it is also possible to use toxic anti-bacterials for longer periods than if the anti-bacterial was used on its own.

Fulhold has sponsored research at a number of institutions to show the effectiveness of CHD-FA against a wide range of bacteria. Most recently this research included studies of the effectiveness of CHD-FA against bacteria with the NDM-1 resistance. In all cases to date CHD-FA has been shown to be an effective anti-baterial, without exception.

In vitro Bactimm data

Bactimm is an institute in Holland that completed some comparitive tests to compare CHD-FA to Chlorhexidine, a commonly used but toxic anti-bacterial. The extract below shows CHD-FA to be both more effective and less toxic than Chlorhexadine.

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In vitro Assuit University data

Assuit University specialises in infections endemic to the Nile region. The report below shows how CHD-FA was effective against the causes of many of these untreatable conditions.

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Antibiotic Synergy data

Synergy with previously effective, but now ineffective drugs, was demonstrated in this report.

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Cholera data

Cholera is a widespread disease caused by the bacteria Vibrio Cholerae. This report shows the effectiveness of CHD-FA against this bacteria in-vitro.

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Clostridium data

Clostridium is an agent of serious infections that is becoming resistant and is increasingly a problem in hospitals. Clostridium difficile can casue diarrhea that is particularly dangerous to infants. Resistance is particularly successful in the sporolation phase where the bacteria forms a hard resistant surface membrane that protects it from many treatments. This report shows the effectiveness of CHD-FA in treating Clostridium in both the vegetative and sporolated phases.

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Validated Report on the in-vivo Efficacy of CHD-FA Against MRSA

MRSA is otherwise known as the "superbug" and has become major problem for hospitals worldwide. The summary findings are;
  • Experiments were established using 0.2ml gavages of 2% and 0.5% CHD-FA twice daily (equivalent to 2% and 0.5% CHD-FA administered at 8ml/kg).
  • 8ml/kg of 2% or 0.5% CHD-FA buffered to pH was well tolerated in mice.
  • 8ml/kg of 2% or 0.5% CHD-FA was effective at reducing the kidney burden in mice infected with Methicillin Resistant Staphylococcus aureus. The burden following treatment was significantly lower than vehicle treated mice (~1.24 and 0.7 log10 cfu/gram reduction respectively).
  • 8ml/kg of 2% or 0.5% CHD-FA was extremely effective when used in combination with cloxacillin (even though the strain is highly resistant to cloxacillin as monotherapy). The combined reduction in tissue burden was significantly superior to either treatment used as monotherapy.
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In vitro efficacy of CHD-FA against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa

University of Pretoria Report on the in vitro efficacy of CHD-FA against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa - September 2008. This research was completed to show the effectiveness of CHD-FA against animal variants of these common bacteria.

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Multi-Resistant Enterobacteriaceae and Mycobacteria

The NDM-1 gene mutation has conferred resistance on a number of bacteria classes. CHD-FA was effective against these mutations where conventional drugs were not effective. CHD-FA was also tested against a Mycobacterium that is commonly used as a surrogate to determine whether there may be effectiveness against TB. Again, CHD-FA was effective against Mycobacterium smegmatis and compared favourably to other drugs used in the tests.

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